Semax 5 Mg
Semax is a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH 4-10 fragment) designed for increased stability and penetration into the central nervous system. The sequence is Met-Glu-His-Phe-Pro-Gly-Pro with N-terminal acetylation. Semax is studied in laboratory settings for its potential effects on neurotrophic factor expression, neurotransmitter modulation, neuroprotection, cognitive processes, and adaptation to stress or ischemic conditions. Manufactured in the USA, it has a purity of
≥99% as determined by HPLC and is available as lyophilized powder in packs of 5mg or 10mg vials.
Semax is for in vitro and in vivo laboratory research use only, not human consumption, therapeutic use, or any other non-research application.
Semax Mechanism of Action in Research Environment
In experimental models, Semax modulates various neurotransmitter systems. It increases brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression in hippocampal and cortical neurons. It enhances dopamine and serotonin turnover in the striatum and frontal cortex and supports stress resilience through modulation of enkephalin and dynorphin systems. Semax also induces tyrosine hydroxylase expression and increases the density of dopamine D1/D2 receptors in specific brain regions. Semax has demonstrated anti-inflammatory effects through suppression of IL-6 and TNF-α production in neuroinflammatory models, while also protecting against oxidative stress and excitotoxicity in neuronal cultures. These mechanisms are studied in research related to neuroprotection, cognition, memory consolidation, and adaptation to stress or ischemic conditions.
Semax Peptide Sequence
Semax (N-terminal acetylation) is a linear acetylated heptapeptide:
Ac-Met-Glu-His-Phe-Pro-Gly-Pro (Ac-MEHFPGP) Molecular Formula
C₃₇H₅₁N₉O₁₀S
Molecular Weight
813.93 Da
CAS Number
80714-61-0 The sequence is derived from ACTH 4–10 with proline substitutions and C-terminal modification to improve stability and CNS penetration.
Semax 5mg
Semax 5mg provides a practical dosage for smaller or preliminary research protocols. It is suitable for pilot experiments, dose-response studies, or projects requiring precise low-volume aliquots without excess material. This format is useful for limited in vitro assays or small-group rodent studies investigating Semax’s effects on neurotrophic factor expression and neurotransmitter modulation. The 5mg format allows efficient reconstitution and minimizes reagent loss while maintaining ≥99% HPLC purity and stability.
Potential Research-Based Benefits of Semax
1. Neuroprotective Effects in Ischemic Models
In rat models of focal cerebral ischemia, Semax administered at 50–250 µg/kg i.p. produced a dose-dependent reduction in infarct volume (30–50%), improved neurological scores, and increased BDNF and NGF expression in peri-infarct regions.
2. Cognitive and Memory Enhancement
In learning and memory studies such as the Morris water maze and passive avoidance tests, Semax improved acquisition and retention, particularly in conditions involving ischemia or neurotoxicity. Doses between
100–300 µg/kg improved performance in both young and aged rats and correlated with increased BDNF levels in the hippocampus and frontal cortex.
3. Stress and Anxiety-Related Behavior
In chronic stress models, Semax normalized anxiety-like behavior in elevated plus-maze and open-field tests. It restored dopamine and serotonin levels in stress-affected brain regions and prevented stress-related immune suppression.
4. Neurochemical and Immunomodulatory Actions
Semax increases dopamine and serotonin turnover in the striatum and frontal cortex, enhances tyrosine hydroxylase activity, and alters dopamine receptor density. In glial cultures, it reduces pro-inflammatory cytokines (IL-6 and TNF-α) and promotes anti-inflammatory responses, making it relevant for neuroinflammation research.
5. In Vitro Neuroprotection
In neuronal cultures, Semax protects against glutamate-induced excitotoxicity and oxidative damage. It preserves mitochondrial function and reduces caspase activation in oxidative stress models. Semax remains investigational and is not approved for therapeutic use.
Semax 10mg
Semax 10mg is more suitable for extended or multi-dose research protocols. It supports longer-term behavioral studies, tissue analyses, and neurochemistry experiments requiring higher total peptide quantities. This size allows researchers to scale from pilot experiments to larger studies while maintaining ≥99% purity and lyophilized stability.
How To Handle Semax
Handling Tips
- Do not shake vigorously (gently swirl if needed)
- Use sterile technique during reconstitution
- Minimize time outside the refrigerator
- Discard solution if it becomes cloudy or discolored
Important Disclaimer
Semax is an experimental research peptide intended only for in vitro or in vivo experimental studies. It has not been evaluated by the FDA, EMA, or other regulatory authorities for therapeutic use. Human outcomes cannot be predicted from preclinical data. No claims regarding safety, efficacy, or benefits in humans are made. Handle only in qualified research laboratories under appropriate oversight.
For laboratory research use only — not for human or veterinary consumption. Referenced Citations
