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Oxytocin – 2mg

Name: Oxytocin - 2mg - Orion Peptides
Price: 31.00 USD
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Oxytocin is a naturally occurring nonapeptid hormone, which is synthesized in the hypothalamus and secreted by the posterior pituitary gland.

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Oxytocin 2mg | 99% Purity (USA Made) | Research Peptide

Oxytocin is a naturally occurring nonapeptide hormone, which is synthesized in the hypothalamus and secreted by the posterior pituitary gland. It is a nonapeptide that is most well-known in research for its functions in social bonding, reproductive physiology, stress modulation, and neuroendocrine signaling. Synthetic Oxytocin is studied in the laboratory regarding its role in the contraction of uterine smooth muscle, milk ejection, pair-bonding behaviors (in mammals), attenuation of anxiety and pain perception, as well as through anti-inflammatory pathways. It is supplied as high-purity lyophilized powder ( ≥99% via HPLC ) in 2mg vials, manufactured in the USA. Oxytocin is designed only for in vitro and in vivo laboratory research — not intended for human consumption, therapeutic use, or any non-research application, they wrote.

Oxytocin Mechanism of Action in Research

Oxytocin acts mainly by binding to the oxytocin receptor (OXTR), a class I G-protein-coupled receptor expressed in the uterus, mammary glands, brain (e.g., amygdala, hypothalamus, nucleus accumbens), and immune cells. Upon binding and receptor activation, the G protein coupled to the receptors is activated, leading to G_q/11-protein signaling via phospholipase C and IP3 pathway, increasing intracellular calcium and causing smooth muscle contraction (uterine myometrium) and secretion (milk ejection). Oxytocin also acts centrally by modulating the GABAergic and glutamatergic transmission, stimulating dopamine secretion in reward pathways, lowering amygdala activity with consequent anxiolytic and prosocial effects in behavioral models. It also mediates vasopressin pathways through partial cross-reactivity with V1a receptors, and it has been shown to exert anti-inflammatory effects by inhibiting NF-κB and pro-inflammatory cytokines (TNF-α, IL-6) in immune cells. These mechanisms are examined in models of social behavior, reproduction, stress resilience, pain modulation, and neuroinflammation.

Oxytocin Peptide Sequence

Oxytocin is a cyclic nonapeptide that contains a disulfide bond between Cys¹ and Cys⁶: Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH₂ (disulfide bond: Cys¹–Cys⁶)

Molecular formula:

C₄₃H₆₆N₁₂O₁₂S₂

Molecular weight:

1007.19 Da

CAS Number:

50-56-6

PubChem CID:

439303 C-terminal amidation and a disulfide bridge are important for receptor binding affinity and biological stability.

Oxytocin Research

1. Reproductive and Uterine Effects

Oxytocin induces dose-dependent contractions through OXTR-mediated calcium influx in isolated uterine smooth muscle preparations and animal models. Research demonstrates that it improves myometrial contractility under labor-like conditions and facilitates milk ejection via mammary gland myoepithelial cell activation. Studies have addressed their involvement in the timing of parturition, involution of the postpartum uterus, and lactation physiology. Note: These studies are still limited and only true in the research environment. Oxytocin is not approved by the FDA for human consumption.

2. Social Behavior and Bonding

In rodent and primate models, Oxytocin administration (intracerebroventricular or peripheral) engages in pair-bonding, maternal care, and social recognition more readily. It increases time spent in social proximity, reduces aggression, and induces behaviour similar to trust in cooperative tasks. These effects are associated with OXTR activation in the nucleus accumbens and amygdala, which modulate reward and fear circuits.

3. Anxiolytic and Stress-Modulating Properties

Rodents show reduced anxiety-like behaviour on elevated plus-maze (EPM) and open-field tests with oxytocin. It inhibits hypothalamic CRH neurons and attenuates stress-induced ACTH and cortisol secretion. Research indicates it protects heart health and nervous system responses to stressors, with potential relevance in paradigms of anxiety disorders and PTSD.

4. Pain Modulation and Analgesia

Oxytocin exerts antinociceptive effects through both spinal and supraspinal mechanisms in models of acute and chronic pain. It suppresses nociceptive transmission in dorsal horn neurons and potentiates descending inhibitory pathways. Additionally, studies are being conducted on its use in reducing visceral pain, inflammatory hyperalgesia, and postoperative opioid sparing analgesia.

5. Neuroprotective and Anti-Inflammatory Actions

Oxytocin protects against excitotoxicity and oxidative stress in neuronal cultures and an ischemia model. In brain injury models, it decreases both microglial activation and pro-inflammatory cytokine secretion. Research explores its potential role in neurodegenerative diseases and neuroinflammation through oxytocin receptor (OXTR)-mediated anti-apoptotic and immunomodulatory mechanisms. Oxytocin is still investigational — no widespread human approval for non-obstetric uses bolsters its use. What continues to be explored is how it works in social neuroscience, reproductive physiology, stress resilience, pain ad neuroprotection.

Storage and Handling of Oxytocin

Unopened vials: Store at 2–8°C, protect from light and moisture. Do not freeze. Preserved with bacteriostatic water or sterile diluent in azide conditions. Refrigerate reconstituted solutions. To use Preservative within the stability window (usually 4–6 weeks at 2–8°C): Avoid repeated freeze-thaw cycles. Always use sterile technique, gloves, and appropriate PPE.

Important Disclaimer

Oxytocin is an investigational research peptide. For in vitro or in vivo laboratory research use only. Not FDA, EMA, or any authority approved for human therapeutic/reproductive/behavioural/analgesic/medical use outside specific obstetric indications. Research chemical (category: WADA S0 non-approved substances). Preclinical data do not predict human events. No claims are made for safety, efficacy, or benefits in humans. Immunogenicity or impurities could be among the possible risks. Only in qualified research facilities under institutional supervision. For the use of laboratories only — not for human or veterinary consumption.

Referenced Citations

Said SI, Mutt V. (1970). Polypeptide with broad biological activity: isolation from small intestine. Science.
Delgado M, et al. (2004). Vasoactive intestinal peptide: a regulator of innate and adaptive immune responses. Journal of Immunology.
González-Rey E., Delgado M. (2008). Therapeutic potential of VIP in inflammatory diseases. Current Pharmaceutical Design.
Harmar AJ, et al. (2012). VPAC and PAC receptors: From ligands to pharmacology. British Journal of Pharmacology.
Recent motility study: VIP in microbiota-neuroimmune control of intestinal motility. Cellular and Molecular Gastroenterology and Hepatology.

Research Use Only

This product is intended for laboratory research use only. It is not intended for human or animal consumption, or for use in diagnostic or therapeutic procedures.

Chemical Properties

Molecular Formula	C43H66N12O12S2
Molecular Mass	1007.2 g/mol
Monoisotopic Mass	1006.43645793 Da
Polar Area	450 Å²
Complexity	1870
XLogP	-2.6
Heavy Atom Count	69
Hydrogen Bond Donor Count	12
Hydrogen Bond Acceptor Count	15
Rotatable Bond Count	17
CID	439302
InChI	InChI=1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1
InChIKey	XNOPRXBHLZRZKH-DSZYJQQASA-N
IUPAC Name	(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
Smiles	CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N)CC(=O)N)CCC(=O)N

Certificate of Analysis

Quality

Every batch of Oxytocin – 2mg is tested for purity and identity using industry-standard methods.

HPLC Analysis

High-Performance Liquid Chromatography confirms purity ≥98%. Each batch is analyzed to ensure consistent quality.

Mass Spectrometry (MS)

Identity verification via mass spectrometry confirms correct molecular weight of 4113.58 g/mol.

Third-Party Testing

All products undergo independent third-party laboratory testing for quality assurance.

Request COA

Certificate of Analysis documents are available for all products. Contact us with your order number to request batch-specific documentation.

COA Lab Tests

Each product batch is tested by independent laboratories to verify purity, identity, and quality. The Certificate of Analysis (COA) provides transparent lab results, ensuring the product meets strict research-grade standards.

Storage & Handling

Before Use (Unopened)

Store in a refrigerator at 2°C to 8°C (36°F to 46°F)
Keep the temperature constant at all times
Store in the main refrigerator compartment — avoid the door

After Reconstitution (Liquid Form)

Continue storing at 2°C to 8°C (36°F to 46°F)
Keep the liquid form refrigerated between doses
Return to the refrigerator immediately after each use
Do not shake; handle gently to maintain stability

Storage During Travel

Keep in original packaging for protection
Minimize time outside the proper temperature range
Use an insulated cooler pack if traveling for more than 30–60 minutes
Return to the refrigerator as soon as you arrive
Plan for long trips to avoid temperature fluctuations

After Reconstitution (Liquid Form)

Continue storing at 2°C to 8°C (36°F to 46°F)
Keep the liquid form refrigerated between doses
Return to the refrigerator immediately after each use
Do not shake; handle gently to maintain stability

Oxytocin – 2mg

Bulk Pricing – Save More

Oxytocin 2mg | 99% Purity (USA Made) | Research Peptide

Oxytocin Mechanism of Action in Research

Oxytocin Peptide Sequence

Molecular formula:

Molecular weight:

CAS Number:

PubChem CID:

Oxytocin Research

1. Reproductive and Uterine Effects

2. Social Behavior and Bonding

3. Anxiolytic and Stress-Modulating Properties

4. Pain Modulation and Analgesia

5. Neuroprotective and Anti-Inflammatory Actions

Storage and Handling of Oxytocin

Important Disclaimer

Referenced Citations

Research Use Only

Chemical Properties

Certificate of Analysis

Quality

HPLC Analysis

Mass Spectrometry (MS)

Third-Party Testing

Request COA

COA Lab Tests

Storage & Handling

Before Use (Unopened)

After Reconstitution (Liquid Form)

Storage During Travel

After Reconstitution (Liquid Form)

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